General description
SALL4 is a zinc finger transcription factor. Anti-SALL4 demonstrates 100% sensitivity and stains more than 90% tumor cells in all intratubular germ cell neoplasia, seminomas/dysgerminomas, embryonal carcinomas, and yolk sac tumor (YST) (both pediatric and postpubertal). Anti-SALL4 also stains most cases of teratoma and the mononucleated trophoblastic cells in choriocarcinomas. In contrast, non-germ cell tumors show no anti-SALL4 staining. Most non-testicular tumors from various organs and sites are negative for anti-SALL4, though an occasional carcinoma or sarcoma may show weak anti-SALL4 staining in less than 25% of tumor cells. In normal testicular tissue, positive, weak anti-SALL4 staining is observed in spermatogonia. In addition, a few (﹤5%) primary spermatocytes showed dot-like weak anti-SALL4 staining. Secondary spermatocytes, spermatids, spermatozoa, and Sertoli cells are negative for anti-SALL4. Leydig cells, rete testis, epididymis, spermatic cord fibroblasts, blood vessels, and hematopoietic cells are negative for anti-SALL4.
Legal Information
Cell Marque is a trademark of Sigma-Aldrich Co. LLC
Linkage
SALL4 Positive Control Slides, Product No. 385S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Other Notes
For Technical Service please contact: 800-665-7284 or email: [email protected]
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Quality
This product has met the following criteria to qualify for the following awards: